ZNF558

Across TCGA pan-cancer cohorts, ZNF558 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZNF558’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF558 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF558 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where ZNF558 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF558 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.537	<.001	11	view →
COAD	Male	All	+0.516	<.001	10	view →
HNSC	Male	III,IV	+0.749	<.001	9	view →
BLCA	Female	III,IV	+0.685	.007	6	view →
CHOL	Female	All	+1.796	<.001	5	view →
LUSC	Male	II,III,IV	+0.724	<.001	5	view →
LIHC	Male	All	+0.621	<.001	5	view →
THCA	Male	All	−0.496	.001	5	view →
KICH	Female	All	−0.634	.002	3	view →
KIRP	All	IV	+0.807	.001	2	view →
STAD	All	II,III,IV	+0.453	.024	2	view →
READ	All	All	+0.432	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZNF558–KIRC

Open the KIRC breakdown →