ZNF558

Across TCGA cell cohorts, ZNF558 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,126 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ZNF558-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription initiation, Peptidyl-lysine acetylation, and Negative regulation of transcription initiation by RNA polymerase II. Each is linked with ZNF558 in more than 9 cancer types. Because this analysis shows association rather than direction, both ZNF558-to-partner and partner-to-ZNF558 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated transcription initiation grouped by ZNF558-low versus ZNF558-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF558→partner) and Y-score (partner→ZNF558) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of DNA-templated transcription initiation →	+0.101	+1.187	<.001	<.001	2	10
OVARY	Peptidyl-lysine acetylation →	+0.079	+0.937	.004	.009	3	9
SOFT_TISSUE	Negative regulation of transcription initiation by RNA polymerase II →	+0.101	+1.187	<.001	<.001	2	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.177	+1.129	<.001	<.001	3	9
OESOPHAGUS	Golgi to plasma membrane protein transport →	+0.140	+1.666	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Golgi vesicle transport →	+0.075	+0.901	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,126 associations by consensus.

Negative regulation of DNA-templated transcription initiation by ZNF558 expression — SOFT_TISSUE

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