ZNF558

Across TCGA cell cohorts, ZNF558 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF558-associated genes across cancer lineages are CFHR2, SOX3, and TBR1. Each is linked with ZNF558 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF558-to-partner and partner-to-ZNF558 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by ZNF558-low versus ZNF558-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF558→partner) and Y-score (partner→ZNF558) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	1
BLOOD_Leukemia	SOX3 →	+0.021	+4.551	<.001	.004	3	1
LARGE_INTESTINE	TBR1 →	+0.045	+3.333	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CFHR2 by ZNF558 expression — LARGE_INTESTINE

Explore this box plot interactively →