ZNF556

Across TCGA pan-cancer cohorts, ZNF556 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated ZNF556 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher ZNF556 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF556 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

READ, LUSC, and PRAD are the cancer types where ZNF556 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	III,IV	0.111	0.903	<.001	24	view →
LUSC	OS	Median	II,III,IV	0.384	0.738	.004	14	view →
PRAD	OS	Median	All	0.080	0.990	<.001	12	view →
STAD	OS	Median	All	0.095	0.543	.001	12	view →
COAD	OS	Median	II,III,IV	0.267	0.789	.003	7	view →
SKCM	DFS	Median	II,III,IV	0.421	0.195	.004	7	view →
LUAD	DFS	Median	II,III,IV	0.178	0.721	.008	6	view →
UCEC	OS	Median	IV	0.232	0.608	.006	6	view →
THCA	OS	Median	All	0.342	0.955	<.001	3	view →
BLCA	DFS	Median	II,III,IV	1.000	0.608	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

ZNF556–READ (OS)

Open the READ breakdown →