Across TCGA patient cohorts, ZNF555 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF555-associated genes across cancer lineages are EGFR, GSK-3a-b_pS21_S9, and MSH2. Each is linked with ZNF555 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF555-to-partner and partner-to-ZNF555 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF555→partner) and Y-score (partner→ZNF555) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.234	-2.973	<.001	.035	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.419	+1.594	.020	.042	3	1
UCEC	MSH2 →	-0.258	-2.575	.008	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.276	+2.920	.001	.001	3	1
UCEC	Akt_pT308 →	+0.587	+3.321	.028	.009	3	1
UCEC	PRAS40_pT246 →	+0.165	+3.321	.023	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

ZNF555 survival (RNA) · tumor vs normal (RNA) · all ZNF555 data types