ZNF550

Across TCGA cell cohorts, ZNF550 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ZNF550-associated genes across cancer lineages are C14orf177, CTXN3, and RDH8. Each is linked with ZNF550 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF550-to-partner and partner-to-ZNF550 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C14orf177 grouped by ZNF550-low versus ZNF550-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF550→partner) and Y-score (partner→ZNF550) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C14orf177 →	+0.114	+4.922	<.001	.009	3	1
BLOOD_Leukemia	CTXN3 →	+0.012	+5.201	<.001	.006	3	1
BLOOD_Leukemia	RDH8 →	+0.031	+5.201	<.001	.006	3	1
SKIN	OXT →	+0.070	+4.977	<.001	.007	3	1
SKIN	IL2 →	+0.022	+5.415	<.001	.004	3	1
SKIN	SPINK9 →	+0.065	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

C14orf177 by ZNF550 expression — BLOOD_Leukemia

Explore this box plot interactively →