ZNF549

Across TCGA patient cohorts, ZNF549 mutation is significantly associated with the RNA expression of many other genes, with 3,807 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF549-associated genes across cancer lineages are BNIP1, KIF23, and SKA1. Each is linked with ZNF549 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF549-to-partner and partner-to-ZNF549 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP1 grouped by ZNF549-low versus ZNF549-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF549→partner) and Y-score (partner→ZNF549) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BNIP1 →	+0.359	+3.348	.009	.005	2	4
UCEC	KIF23 →	+0.659	+1.903	<.001	<.001	3	3
UCEC	SKA1 →	+0.862	+2.180	<.001	<.001	3	3
UCEC	PBK →	+1.013	+2.496	<.001	<.001	3	3
UCEC	UQCRH →	+0.813	+2.191	<.001	<.001	3	3
COAD	RCC1 →	+0.548	+3.210	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,807 associations by consensus.

BNIP1 by ZNF549 expression — COAD

Explore this box plot interactively →