ZNF547

Across TCGA patient cohorts, ZNF547 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF547-associated genes across cancer lineages are PDCD4, 14-3-3_beta, and eEF2. Each is linked with ZNF547 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF547-to-partner and partner-to-ZNF547 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by ZNF547-low versus ZNF547-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF547→partner) and Y-score (partner→ZNF547) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.740	-3.087	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.070	-2.432	.033	.018	3	1
UCEC	eEF2 →	+0.329	+2.321	.005	.005	3	1
UCEC	EGFR_pY1068 →	-0.245	-2.807	.003	.002	3	1
UCEC	eIF4E →	+0.187	+1.938	.007	.001	3	1
UCEC	A-Raf_pS299 →	-0.109	-2.415	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PDCD4 by ZNF547 expression — UCEC

Explore this box plot interactively →