ZNF547

Across TCGA pan-cancer cohorts, ZNF547 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ZNF547’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF547 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF547 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, LIHC, and KIRP are the cancer types where ZNF547 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF547 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.671	<.001	9	view →
LIHC	Female	All	+0.439	<.001	8	view →
KIRP	All	All	−0.425	<.001	6	view →
CHOL	Female	All	+1.580	<.001	5	view →
KICH	All	All	−0.450	<.001	5	view →
STAD	All	II,III,IV	+0.293	.017	2	view →
PRAD	All	All	+0.235	<.001	2	view →
ESCA	Female	All	+0.593	.042	1	view →
LUAD	Female	III,IV	−0.389	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ZNF547–THCA

Open the THCA breakdown →