ZNF528

Across TCGA cell cohorts, ZNF528 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ZNF528-associated genes across cancer lineages are CAPZA3, OR6T1, and KRTAP5-4. Each is linked with ZNF528 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF528-to-partner and partner-to-ZNF528 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAPZA3 grouped by ZNF528-low versus ZNF528-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF528→partner) and Y-score (partner→ZNF528) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CAPZA3 →	+0.026	+5.169	<.001	.004	3	1
BONE	OR6T1 →	+0.023	+5.169	<.001	.004	3	1
BONE	KRTAP5-4 →	+0.033	+5.169	<.001	.004	3	1
BONE	ANTXRL →	+0.033	+5.169	<.001	.004	3	1
LUNG_NSCLC_LUAD	C1orf232 →	+0.037	+4.887	<.001	.009	3	1
LUNG_SCLC	BPIFB6 →	+0.016	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

CAPZA3 by ZNF528 expression — BONE

Explore this box plot interactively →