ZNF519

Across TCGA pan-cancer cohorts, ZNF519 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF519 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ZNF519 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF519 expression acts as an unfavorable survival marker.

SKCM, LUAD, and LGG are the cancer types where ZNF519 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	II,III,IV	0.231	0.737	<.001	27	view →
LUAD	DFS	Median	All	0.154	0.816	<.001	22	view →
LGG	OS	Median	All	0.173	0.830	<.001	12	view →
COAD	OS	Median	III,IV	0.168	0.691	.041	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF519–SKCM (OS)

Open the SKCM breakdown →