ZNF519

Across TCGA patient cohorts, ZNF519 mutation is significantly associated with the RNA expression of many other genes, with 1,622 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF519-associated genes across cancer lineages are HMGB1P46, OR10G6, and HMGA1P7. Each is linked with ZNF519 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF519-to-partner and partner-to-ZNF519 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P46 grouped by ZNF519-low versus ZNF519-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF519→partner) and Y-score (partner→ZNF519) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HMGB1P46 →	+0.180	+4.787	<.001	.003	3	3
COAD	OR10G6 →	+0.121	+4.308	.009	.009	3	2
COAD	HMGA1P7 →	+0.154	+4.418	<.001	.008	3	2
SKCM	NACAP6 →	+0.062	+5.408	<.001	.002	3	2
BLCA	MRPL57P7 →	+0.290	+5.497	<.001	.004	3	2
UCEC	RNA5SP182 →	+0.310	+3.214	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,622 associations by consensus.

HMGB1P46 by ZNF519 expression — LUAD

Explore this box plot interactively →