ZNF519

Across TCGA patient cohorts, ZNF519 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF519-associated genes across cancer lineages are eEF2, ERK2, and JNK2. Each is linked with ZNF519 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF519-to-partner and partner-to-ZNF519 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ZNF519-low versus ZNF519-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF519→partner) and Y-score (partner→ZNF519) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.340	+2.321	.021	.034	3	2
UCEC	ERK2 →	+0.194	+2.321	.014	.033	3	2
UCEC	JNK2 →	+0.229	+3.000	.005	.001	3	2
UCEC	TIGAR →	+0.126	+1.833	.046	.016	3	2
UCEC	TSC1 →	-0.167	-1.807	.018	.027	3	2
UCEC	ATM →	-0.639	-2.321	<.001	.006	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eEF2 by ZNF519 expression — UCEC

Explore this box plot interactively →