ZNF519

Across TCGA cell cohorts, ZNF519 mutation is significantly associated with the mutation status of many other genes, with 3,198 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF519-associated genes across cancer lineages are ZBTB3, S1PR4, and MGMT. Each is linked with ZNF519 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF519-to-partner and partner-to-ZNF519 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZBTB3 grouped by ZNF519-low versus ZNF519-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF519→partner) and Y-score (partner→ZNF519) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZBTB3 →	+4.442	+5.095	.001	.001	1	3
LARGE_INTESTINE	S1PR4 →	+4.044	+3.744	.003	.003	1	3
LARGE_INTESTINE	MGMT →	+3.459	+3.459	.006	.006	1	3
BREAST	SPAST →	+4.857	+4.297	.009	.009	1	2
LARGE_INTESTINE	CBX5 →	+3.874	+4.215	<.001	<.001	1	2
LARGE_INTESTINE	FBXL19 →	+3.459	+3.459	.006	.006	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,198 associations by consensus.

ZBTB3 by ZNF519 expression — BREAST

Explore this box plot interactively →