ZNF518B

Across TCGA patient cohorts, ZNF518B mutation is significantly associated with the RNA expression of many other genes, with 5,401 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF518B-associated genes across cancer lineages are R3HCC1, MRPL40, and FBXO16. Each is linked with ZNF518B in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF518B-to-partner and partner-to-ZNF518B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HCC1 grouped by ZNF518B-low versus ZNF518B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF518B→partner) and Y-score (partner→ZNF518B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	R3HCC1 →	+0.529	+2.010	<.001	<.001	3	4
SKCM	MRPL40 →	+0.421	+2.434	<.001	.001	3	3
COAD	FBXO16 →	+0.503	+3.223	.003	.008	3	3
LUSC	RPS27AP14 →	+0.082	+3.195	<.001	.009	3	3
UCEC	GEMIN4 →	+0.478	+2.223	<.001	<.001	3	3
UCEC	POLR2A →	+0.464	+1.491	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,401 associations by consensus.

R3HCC1 by ZNF518B expression — UCEC

Explore this box plot interactively →