ZNF518A

Across TCGA pan-cancer cohorts, ZNF518A RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ZNF518A data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF518A RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZNF518A expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, ACC, and UCS are the cancer types where ZNF518A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.857	0.691	<.001	71	view →
ACC	DFS	Median	All	0.493	0.813	<.001	65	view →
UCS	DFS	Median	IV	0.952	0.367	.001	54	view →
SCLC	DFS	Median	II,III,IV	0.540	0.155	<.001	36	view →
UVM	DFS	Tertile	III,IV	0.230	0.860	<.001	35	view →
KIRC	DFS	Median	All	0.930	0.790	.002	28	view →
READ	OS	Median	II,III,IV	0.801	0.290	<.001	25	view →
BLCA	OS	Quartile	All	0.576	0.377	.019	14	view →
SKCM	DFS	Quartile	All	0.257	0.121	.001	13	view →
CHOL	DFS	Median	All	0.726	0.227	.019	10	view →
LIHC	DFS	Quartile	All	0.442	0.635	.004	9	view →
COAD	OS	Quartile	All	0.954	0.827	.022	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ZNF518A–HNSC (OS)

Open the HNSC breakdown →