ZNF518A

Across TCGA pan-cancer cohorts, ZNF518A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZNF518A’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF518A RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF518A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LIHC are the cancer types where ZNF518A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF518A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.939	<.001	8	view →
KICH	Male	All	−0.993	<.001	7	view →
LIHC	Female	All	+0.774	<.001	6	view →
STAD	All	All	+0.712	.001	6	view →
BLCA	All	All	+0.574	.008	6	view →
CHOL	All	All	+1.807	<.001	5	view →
LUAD	Male	III,IV	+0.598	.014	3	view →
COAD	Female	All	−0.467	.044	1	view →
ESCA	Female	All	+0.416	.041	1	view →
KIRC	Male	III,IV	−0.274	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZNF518A–THCA

Open the THCA breakdown →