Across TCGA pan-cancer cohorts, ZNF512B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF512B data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF512B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF512B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where ZNF512B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	0.702	0.971	<.001	44	view →
CCRCC	DFS	Tertile	All	0.601	0.923	.001	28	view →
PDAC	OS	Tertile	II,III,IV	0.255	0.607	.002	20	view →
UCEC	OS	Median	II,III,IV	1.000	0.620	.011	10	view →
LUAD	OS	Quartile	II,III,IV	0.344	0.839	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ZNF512B tumor-vs-normal RNA expression · all ZNF512B data types