ZNF503-AS2

Across TCGA pan-cancer cohorts, ZNF503-AS2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ZNF503-AS2 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher ZNF503-AS2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZNF503-AS2 expression acts as an unfavorable survival marker, although some lineages such as MESO and HNSC show a favorable association.

MESO, ACC, and HNSC are the cancer types where ZNF503-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.502	0.271	<.001	87	view →
ACC	DFS	Tertile	All	0.169	0.690	<.001	54	view →
HNSC	OS	Tertile	All	0.821	0.677	.001	50	view →
KIRC	DFS	Median	All	0.700	0.552	<.001	47	view →
UCEC	DFS	Median	All	0.859	0.933	.004	38	view →
SKCM	OS	Quartile	All	0.618	0.865	.001	37	view →
LGG	DFS	Median	All	0.338	0.463	<.001	37	view →
PAAD	OS	Median	All	0.545	0.278	.005	21	view →
BLCA	OS	Quartile	All	0.220	0.622	.023	14	view →
SARC	DFS	Quartile	All	0.706	0.502	.002	14	view →
THCA	DFS	Median	All	0.878	0.776	.007	13	view →
OV	OS	Tertile	All	0.758	0.658	.031	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ZNF503-AS2–MESO (OS)

Open the MESO breakdown →