ZNF503-AS2

Across TCGA pan-cancer cohorts, ZNF503-AS2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ZNF503-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF503-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF503-AS2 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where ZNF503-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF503-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.454	<.001	12	view →
HNSC	Female	IV	+0.906	<.001	11	view →
THCA	Male	III,IV	−0.924	<.001	10	view →
LIHC	All	II,III,IV	+0.972	<.001	8	view →
LUSC	Female	All	+0.982	<.001	6	view →
KICH	All	All	−0.683	.001	6	view →
COAD	All	All	+0.338	<.001	6	view →
BLCA	Male	All	+0.944	.013	5	view →
KIRP	Male	All	−0.650	<.001	5	view →
BRCA	All	II,III,IV	−0.301	<.001	4	view →
CHOL	Male	All	+0.871	<.001	2	view →
PRAD	All	All	+0.205	.045	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ZNF503-AS2–KIRC

Open the KIRC breakdown →