ZNF496

Across TCGA cell cohorts, ZNF496 mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF496-associated genes across cancer lineages are KRTAP4-8, SLC25A35, and SCO1. Each is linked with ZNF496 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF496-to-partner and partner-to-ZNF496 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-8 grouped by ZNF496-low versus ZNF496-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF496→partner) and Y-score (partner→ZNF496) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP4-8 →	+0.287	+3.736	.005	.008	3	2
LARGE_INTESTINE	SLC25A35 →	+0.854	+3.364	<.001	.002	3	2
LARGE_INTESTINE	SCO1 →	+0.614	+3.364	.003	.002	3	2
LUNG_NSCLC_LUAD	UGT2B4 →	+1.140	+3.544	<.001	.007	3	2
UPPER_AERODIGESTIVE_TRACT	CT45A7 →	+0.052	+4.209	<.001	.006	3	1
BLOOD_Leukemia	HRG →	+0.307	+3.177	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

KRTAP4-8 by ZNF496 expression — SOFT_TISSUE

Explore this box plot interactively →