ZNF491

Across TCGA cell cohorts, ZNF491 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF491-associated genes across cancer lineages are TECRL, GPR42, and OR2L5. Each is linked with ZNF491 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF491-to-partner and partner-to-ZNF491 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TECRL grouped by ZNF491-low versus ZNF491-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF491→partner) and Y-score (partner→ZNF491) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TECRL →	+0.026	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	GPR42 →	+0.016	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR2L5 →	+0.012	+4.887	.001	.009	3	1
OVARY	GPR148 →	+0.054	+4.095	<.001	.003	3	1
BLOOD_Leukemia	OR4D9 →	+0.006	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

TECRL by ZNF491 expression — LARGE_INTESTINE

Explore this box plot interactively →