ZNF487

Across TCGA patient cohorts, ZNF487 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF487-associated genes across cancer lineages are Ku80, YB-1_pS102, and PDCD4. Each is linked with ZNF487 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF487-to-partner and partner-to-ZNF487 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ZNF487-low versus ZNF487-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF487→partner) and Y-score (partner→ZNF487) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.335	+3.183	.009	.010	3	1
UCEC	YB-1_pS102 →	-0.221	-3.169	.030	.020	3	1
UCEC	PDCD4 →	-0.803	-3.169	.001	.020	2	1
UCEC	TFRC →	+0.777	+3.169	.007	.020	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Ku80 by ZNF487 expression — UCEC

Explore this box plot interactively →