ZNF487

Across TCGA pan-cancer cohorts, ZNF487 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ZNF487’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF487 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF487 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KIRC, KICH, and LUSC are the cancer types where ZNF487 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF487 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+0.345	<.001	11	view →
KICH	Female	III,IV	−1.423	<.001	10	view →
LUSC	All	II,III,IV	−0.734	<.001	7	view →
THCA	Male	III,IV	−0.451	<.001	7	view →
LIHC	Female	All	+0.285	<.001	7	view →
LUAD	Female	II,III,IV	−0.438	.006	5	view →
KIRP	All	IV	+0.752	.021	4	view →
CHOL	Male	All	+1.286	<.001	3	view →
HNSC	Male	III,IV	+0.403	.010	3	view →
UCEC	All	All	−0.414	.024	2	view →
PAAD	Female	All	+0.300	.044	2	view →
PRAD	All	All	−0.151	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ZNF487–KIRC

Open the KIRC breakdown →