ZNF483

Across TCGA patient cohorts, ZNF483 mutation is significantly associated with the RNA expression of many other genes, with 3,263 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF483-associated genes across cancer lineages are INCENP, DBF4B, and PLA2G3. Each is linked with ZNF483 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF483-to-partner and partner-to-ZNF483 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INCENP grouped by ZNF483-low versus ZNF483-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF483→partner) and Y-score (partner→ZNF483) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	INCENP →	+0.580	+3.613	.005	.001	3	3
UCEC	DBF4B →	+0.551	+1.893	<.001	<.001	3	3
UCEC	PLA2G3 →	+0.716	+1.893	<.001	<.001	3	3
UCEC	NDUFAF5 →	+0.348	+2.445	<.001	<.001	3	3
UCEC	CMC2 →	+0.453	+2.169	<.001	<.001	3	3
UCEC	INVS →	+0.382	+2.534	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,263 associations by consensus.

INCENP by ZNF483 expression — SKCM

Explore this box plot interactively →