ZNF483

Across TCGA patient cohorts, ZNF483 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF483-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and FoxM1. Each is linked with ZNF483 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF483-to-partner and partner-to-ZNF483 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNF483-low versus ZNF483-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF483→partner) and Y-score (partner→ZNF483) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.606	+2.815	<.001	.036	2	4
UCEC	EGFR_pY1068 →	-0.266	-2.000	.002	.003	3	2
UCEC	FoxM1 →	+0.184	+2.000	.044	.003	3	2
UCEC	JNK_pT183_Y185 →	-0.124	-1.700	.036	.042	3	2
UCEC	Annexin-1 →	+0.625	+2.720	<.001	.003	3	2
UCEC	Shc_pY317 →	-0.164	-2.222	.002	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Caspase-7-cleavedD198 by ZNF483 expression — COAD

Explore this box plot interactively →