ZNF48

Across TCGA patient cohorts, ZNF48 mutation is significantly associated with the RNA expression of many other genes, with 2,802 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF48-associated genes across cancer lineages are BRD1, SEC23A, and MAPRE1. Each is linked with ZNF48 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF48-to-partner and partner-to-ZNF48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRD1 grouped by ZNF48-low versus ZNF48-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF48→partner) and Y-score (partner→ZNF48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BRD1 →	+0.494	+1.912	.001	.004	3	2
UCEC	SEC23A →	+0.592	+2.815	.001	.001	3	2
UCEC	MAPRE1 →	+0.419	+2.609	.009	.005	3	2
UCEC	TMEM269 →	+0.251	+3.424	<.001	<.001	3	2
SKCM	FLT1 →	+0.739	+2.706	.006	.003	3	2
UCEC	PLEKHJ1 →	+0.437	+2.747	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,802 associations by consensus.

BRD1 by ZNF48 expression — UCEC

Explore this box plot interactively →