ZNF48

Across TCGA patient cohorts, ZNF48 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF48-associated genes across cancer lineages are mTOR_pS2448, PTEN, and ATM. Each is linked with ZNF48 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF48-to-partner and partner-to-ZNF48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ZNF48-low versus ZNF48-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF48→partner) and Y-score (partner→ZNF48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.151	-2.308	.012	.033	3	2
UCEC	PTEN →	-0.473	-3.087	.003	<.001	3	2
UCEC	ATM →	-0.473	-1.906	.009	.016	3	2
UCEC	eIF4E →	+0.225	+3.700	.008	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.185	-1.893	.006	.016	3	1
UCEC	JNK2 →	+0.184	+2.834	.021	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

mTOR_pS2448 by ZNF48 expression — UCEC

Explore this box plot interactively →