ZNF474-AS1

Across TCGA pan-cancer cohorts, ZNF474-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ZNF474-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher ZNF474-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF474-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and UCEC show a favorable association.

KICH, UCS, and LGG are the cancer types where ZNF474-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	III,IV	0.172	1.000	<.001	80	view →
UCS	DFS	Median	III,IV	0.509	0.165	.017	52	view →
LGG	OS	Median	All	0.733	0.889	<.001	39	view →
COAD	DFS	Tertile	All	0.366	0.553	<.001	38	view →
UCEC	OS	Quartile	All	0.965	0.881	.001	38	view →
LIHC	OS	Quartile	II,III,IV	0.199	0.495	.002	35	view →
BRCA	DFS	Tertile	IV	0.899	0.427	.007	28	view →
CESC	OS	Tertile	All	0.883	0.717	.001	26	view →
READ	OS	Tertile	III,IV	0.687	0.976	.011	21	view →
ACC	OS	Tertile	IV	0.438	0.811	.012	19	view →
ESCA	DFS	Quartile	IV	0.826	0.343	.049	12	view →
LUSC	OS	Quartile	All	0.293	0.514	.004	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ZNF474-AS1–KICH (DFS)

Open the KICH breakdown →