ZNF474-AS1

Across TCGA pan-cancer cohorts, ZNF474-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ZNF474-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ZNF474-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF474-AS1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and BRCA are the cancer types where ZNF474-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF474-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−1.310	<.001	8	view →
LUAD	Female	All	−1.044	<.001	8	view →
BRCA	All	II,III,IV	+0.257	<.001	6	view →
CHOL	All	II,III,IV	+0.415	<.001	4	view →
BLCA	All	All	+0.171	.024	3	view →
THCA	Female	All	−0.543	.002	2	view →
KIRP	All	All	+0.209	.005	2	view →
KIRC	Male	All	+0.110	.019	1	view →
COAD	Female	All	+0.109	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ZNF474-AS1–LUSC

Open the LUSC breakdown →