ZNF467

Across TCGA patient cohorts, ZNF467 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF467-associated genes across cancer lineages are eIF4E, ERK2, and ATM. Each is linked with ZNF467 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF467-to-partner and partner-to-ZNF467 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNF467-low versus ZNF467-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF467→partner) and Y-score (partner→ZNF467) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.178	+2.700	.021	.006	3	2
UCEC	ERK2 →	+0.204	+3.807	.003	<.001	3	2
UCEC	ATM →	-0.536	-2.247	.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.207	-2.247	.024	.001	3	1
UCEC	JNK2 →	+0.327	+3.727	<.001	<.001	3	1
UCEC	MEK1 →	+0.305	+1.847	.023	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

eIF4E by ZNF467 expression — UCEC

Explore this box plot interactively →