ZNF462

Across TCGA cell cohorts, ZNF462 mutation is significantly associated with the RNA expression of many other genes, with 2,368 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF462-associated genes across cancer lineages are CCNF, THAP5, and CDNF. Each is linked with ZNF462 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF462-to-partner and partner-to-ZNF462 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNF grouped by ZNF462-low versus ZNF462-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF462→partner) and Y-score (partner→ZNF462) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCNF →	+0.617	+2.614	.005	.003	3	3
LARGE_INTESTINE	THAP5 →	+0.704	+2.364	<.001	<.001	3	3
BLOOD_Leukemia	CDNF →	+0.498	+3.321	<.001	.005	3	3
BLOOD_Leukemia	ASAP3 →	+1.395	+2.674	<.001	.003	3	3
LARGE_INTESTINE	CASP2 →	+0.534	+3.321	.001	.002	3	3
LARGE_INTESTINE	SEPSECS →	+0.650	+1.850	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,368 associations by consensus.

CCNF by ZNF462 expression — BLOOD_Leukemia

Explore this box plot interactively →