ZNF460-AS1

Across TCGA pan-cancer cohorts, ZNF460-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZNF460-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ZNF460-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF460-AS1 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

LIHC, KIRC, and BRCA are the cancer types where ZNF460-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF460-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	II,III,IV	+0.429	<.001	8	view →
KIRC	All	II,III,IV	−0.301	<.001	8	view →
BRCA	Female	II,III,IV	−0.372	<.001	4	view →
CHOL	Female	All	+1.393	<.001	3	view →
ESCA	All	II,III,IV	+1.055	.034	2	view →
UCEC	All	All	−0.525	.006	2	view →
COAD	All	II,III,IV	+0.283	.023	2	view →
HNSC	Male	II,III,IV	−0.256	.023	2	view →
READ	All	All	+0.513	.046	1	view →
KIRP	All	All	−0.373	.031	1	view →
LUAD	All	All	+0.274	.014	1	view →
LUSC	All	All	+0.219	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZNF460-AS1–LIHC

Open the LIHC breakdown →