ZNF451

Across TCGA patient cohorts, ZNF451 protein abundance is significantly associated with the RNA expression of many other genes, with 11,525 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ZNF451-associated genes across cancer lineages are MCM3, SAYSD1, and ZBTB24. Each is linked with ZNF451 in more than 5 cancer types. Because this analysis shows association rather than direction, both ZNF451-to-partner and partner-to-ZNF451 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZNF451 versus MCM3 in LSCC, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF451→partner) and Y-score (partner→ZNF451) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MCM3 →	+0.798	+0.274	<.001	<.001	3	6
LSCC	SAYSD1 →	+0.407	+0.196	<.001	<.001	3	6
LSCC	ZBTB24 →	+0.460	+0.224	<.001	<.001	3	6
LSCC	MMS22L →	+0.737	+0.258	<.001	<.001	3	6
LSCC	CENPQ →	+0.706	+0.275	<.001	<.001	3	6
LSCC	C1orf112 →	+0.834	+0.333	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,525 associations by consensus.

ZNF451 vs MCM3 — LSCC

Explore this scatter interactively →