ZNF451

Across TCGA pan-cancer cohorts, ZNF451 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ZNF451 data layer compared with 9 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZNF451 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF451 expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRC show a favorable association.

LUAD, KIRC, and HNSC are the cancer types where ZNF451 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.717	0.292	<.001	77	view →
KIRC	DFS	Quartile	All	0.890	0.697	.002	44	view →
HNSC	OS	Median	All	0.487	0.307	.005	39	view →
THYM	DFS	Tertile	All	0.780	0.555	.005	33	view →
SARC	OS	Tertile	All	0.633	0.895	<.001	31	view →
KIRP	DFS	Median	III,IV	0.147	0.578	.008	30	view →
MESO	DFS	Median	II,III,IV	0.234	0.667	.001	30	view →
KICH	DFS	Median	III,IV	0.318	0.901	.004	25	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	24	view →
LIHC	DFS	Quartile	All	0.416	0.614	.004	21	view →
SKCM	DFS	Quartile	All	0.656	0.474	.002	20	view →
UCS	OS	Quartile	II,III,IV	0.571	0.220	.026	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ZNF451–LUAD (DFS)

Open the LUAD breakdown →