ZNF451

Across TCGA patient cohorts, ZNF451 mutation is significantly associated with the RNA expression of many other genes, with 4,569 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF451-associated genes across cancer lineages are TIPIN, TNFSF13B, and CBX3P6. Each is linked with ZNF451 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF451-to-partner and partner-to-ZNF451 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIPIN grouped by ZNF451-low versus ZNF451-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF451→partner) and Y-score (partner→ZNF451) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIPIN →	+0.504	+2.136	<.001	<.001	3	4
BLCA	TNFSF13B →	+1.113	+3.364	.005	.004	3	3
CESC	CBX3P6 →	+0.078	+4.559	<.001	.006	3	3
UCEC	CLEC12A →	+0.366	+1.670	<.001	<.001	3	3
UCEC	MSR1 →	+0.564	+2.021	<.001	<.001	3	3
BLCA	RGS1 →	+1.397	+3.357	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,569 associations by consensus.

TIPIN by ZNF451 expression — UCEC

Explore this box plot interactively →