ZNF451

Across TCGA patient cohorts, ZNF451 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF451-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and Rad50. Each is linked with ZNF451 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF451-to-partner and partner-to-ZNF451 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNF451-low versus ZNF451-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF451→partner) and Y-score (partner→ZNF451) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Caspase-7-cleavedD198 →	+0.639	+3.169	.036	.019	3	4
UCEC	ASNS →	+0.363	+1.584	<.001	.008	3	4
UCEC	Rad50 →	-0.187	-1.485	.008	.003	3	3
UCEC	c-Kit →	-0.214	-1.906	.001	<.001	3	3
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.787	+2.700	.001	.006	3	3
COAD	MIG-6 →	+0.168	+2.866	.001	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Caspase-7-cleavedD198 by ZNF451 expression — BLCA

Explore this box plot interactively →