ZNF451

Across TCGA cell cohorts, ZNF451 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,780 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF451-associated GO terms across cancer lineages are Protein modification by small protein removal, Positive regulation of organelle assembly, and Protein sumoylation. Each is linked with ZNF451 in more than 16 cancer types. Because this analysis shows association rather than direction, both ZNF451-to-partner and partner-to-ZNF451 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein modification by small protein removal grouped by ZNF451-low versus ZNF451-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF451→partner) and Y-score (partner→ZNF451) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Protein modification by small protein removal →	+0.063	+0.740	<.001	<.001	3	17
BLOOD_Myeloma	Positive regulation of organelle assembly →	+0.085	+0.752	<.001	<.001	3	16
LUNG_SCLC	Protein sumoylation →	+0.104	+0.634	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Microtubule organizing center organization →	+0.103	+0.742	<.001	<.001	3	16
PANCREAS	Regulation of transcription initiation by RNA polymerase II →	+0.066	+0.593	.005	<.001	3	15
SOFT_TISSUE	Protein-DNA complex assembly →	+0.068	+0.647	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,780 associations by consensus.

Protein modification by small protein removal by ZNF451 expression — SOFT_TISSUE

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