ZNF451

Across TCGA cell cohorts, ZNF451 mutation is significantly associated with the RNA expression of many other genes, with 784 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF451-associated genes across cancer lineages are ASB5, COL18A1, and FBXO25. Each is linked with ZNF451 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF451-to-partner and partner-to-ZNF451 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB5 grouped by ZNF451-low versus ZNF451-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF451→partner) and Y-score (partner→ZNF451) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ASB5 →	+0.362	+3.369	.006	.006	3	2
LUNG_NSCLC_LUAD	COL18A1 →	-1.736	-3.212	<.001	.007	3	2
LARGE_INTESTINE	FBXO25 →	+0.853	+2.700	<.001	.001	3	2
LARGE_INTESTINE	PLPBP →	+0.701	+2.545	<.001	<.001	3	2
LARGE_INTESTINE	RPP38 →	+0.356	+2.043	.001	.001	3	2
LARGE_INTESTINE	AHCYL2 →	+1.114	+2.389	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 784 associations by consensus.

ASB5 by ZNF451 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →