Across TCGA patient cohorts, ZNF445 mutation is significantly associated with the RNA expression of many other genes, with 4,000 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF445-associated genes across cancer lineages are RPL23AP7, DCLRE1B, and MYL12B. Each is linked with ZNF445 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF445-to-partner and partner-to-ZNF445 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF445→partner) and Y-score (partner→ZNF445) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL23AP7 →	+0.409	+1.784	.008	.008	3	3
UCEC	DCLRE1B →	+0.513	+2.761	<.001	<.001	3	3
SKCM	MYL12B →	+0.376	+2.836	.003	.001	3	3
SKCM	ITGB1BP1 →	+0.565	+2.201	<.001	.001	3	3
UCEC	TUFM →	+0.349	+2.595	<.001	<.001	3	3
UCEC	C14orf119 →	+0.268	+2.294	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,000 associations by consensus.

Exploration

ZNF445 survival (RNA) · tumor vs normal (RNA) · all ZNF445 data types