ZNF444

Across TCGA cell cohorts, ZNF444 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,495 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF444-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cellular anatomical structure, Symbiont-mediated disruption of host anatomical structure, and Negative regulation of calcium ion export across plasma membrane. Each is linked with ZNF444 in more than 15 cancer types. Because this analysis shows association rather than direction, both ZNF444-to-partner and partner-to-ZNF444 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cellular anatomical structure grouped by ZNF444-low versus ZNF444-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF444→partner) and Y-score (partner→ZNF444) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Symbiont-mediated disruption of host cellular anatomical structure →	+0.153	+1.058	<.001	<.001	3	16
BREAST	Symbiont-mediated disruption of host anatomical structure →	+0.153	+1.058	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.080	+1.089	<.001	<.001	3	14
BONE	CAMP/PKA signal transduction →	+0.296	+1.331	<.001	<.001	3	14
KIDNEY	Regulation of protein localization to endoplasmic reticulum →	+0.136	+0.721	<.001	.007	3	14
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.174	+0.821	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,495 associations by consensus.

Symbiont-mediated disruption of host cellular anatomical structure by ZNF444 expression — BREAST

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