ZNF444

Across TCGA pan-cancer cohorts, ZNF444 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ZNF444 data layer compared with 1 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher ZNF444 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF444 expression acts as an unfavorable survival marker, although some lineages such as BLCA and CESC show a favorable association.

MESO, ACC, and KIRC are the cancer types where ZNF444 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	II,III,IV	0.464	0.702	.002	91	view →
ACC	OS	Tertile	All	0.424	0.838	<.001	86	view →
KIRC	DFS	Quartile	All	0.471	0.700	<.001	81	view →
SKCM	DFS	Tertile	All	0.642	0.795	<.001	55	view →
LGG	DFS	Median	All	0.650	0.824	<.001	44	view →
BLCA	OS	Tertile	II,III,IV	0.753	0.608	.005	42	view →
LIHC	OS	Tertile	II,III,IV	0.305	0.555	.005	31	view →
UVM	DFS	Median	II,III,IV	0.394	0.716	.006	31	view →
CHOL	DFS	Tertile	All	0.162	0.679	.001	18	view →
PRAD	DFS	Median	All	0.848	0.922	.005	14	view →
CESC	OS	Median	IV	0.679	0.105	.007	12	view →
THYM	OS	Median	All	1.000	0.654	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ZNF444–MESO (OS)

Open the MESO breakdown →