ZNF444

Across TCGA cell cohorts, ZNF444 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF444-associated genes across cancer lineages are ADH1A, GALR3, and CX3CR1. Each is linked with ZNF444 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF444-to-partner and partner-to-ZNF444 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADH1A grouped by ZNF444-low versus ZNF444-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF444→partner) and Y-score (partner→ZNF444) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADH1A →	+0.105	+3.505	.001	<.001	3	2
LARGE_INTESTINE	GALR3 →	+0.139	+3.602	<.001	.005	3	1
LARGE_INTESTINE	CX3CR1 →	+0.191	+3.252	<.001	.009	3	1
LARGE_INTESTINE	GKN1 →	+0.048	+3.247	<.001	.001	3	1
LARGE_INTESTINE	ARL13A →	+0.071	+3.632	<.001	.003	3	1
LARGE_INTESTINE	OLIG1 →	+0.098	+2.716	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ADH1A by ZNF444 expression — LARGE_INTESTINE

Explore this box plot interactively →