ZNF443

Across TCGA patient cohorts, ZNF443 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF443-associated genes across cancer lineages are p62 Lck ligand, EGFR_pY1068, and FoxM1. Each is linked with ZNF443 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF443-to-partner and partner-to-ZNF443 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ZNF443-low versus ZNF443-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF443→partner) and Y-score (partner→ZNF443) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.332	+1.594	.011	.042	3	2
UCEC	EGFR_pY1068 →	-0.285	-3.584	.004	.002	3	1
UCEC	FoxM1 →	+0.266	+1.906	.010	.016	3	1
UCEC	Gab2 →	+0.441	+2.999	.002	.035	3	1
UCEC	GAPDH →	+0.543	+2.584	.011	.010	3	1
UCEC	INPP4B →	-0.342	-3.584	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

p62 Lck ligand by ZNF443 expression — UCEC

Explore this box plot interactively →