Across TCGA cell cohorts, ZNF442 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF442-associated genes across cancer lineages are HFE, PCCB, and PKDREJ. Each is linked with ZNF442 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF442-to-partner and partner-to-ZNF442 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF442→partner) and Y-score (partner→ZNF442) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HFE →	+0.969	+3.087	.002	.006	3	1
LARGE_INTESTINE	PCCB →	+0.644	+3.125	.001	.008	3	1
LARGE_INTESTINE	PKDREJ →	+0.281	+3.215	<.001	.009	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.495	+3.035	<.001	.003	3	1
LARGE_INTESTINE	ZNF490 →	+0.470	+3.215	.004	.009	3	1
STOMACH	TRIM49D2 →	+0.040	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

ZNF442 survival (RNA) · tumor vs normal (RNA) · all ZNF442 data types