ZNF440

Across TCGA patient cohorts, ZNF440 mutation is significantly associated with the RNA expression of many other genes, with 5,363 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF440-associated genes across cancer lineages are MRPL46, MYL12A, and UQCRC1. Each is linked with ZNF440 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF440-to-partner and partner-to-ZNF440 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL46 grouped by ZNF440-low versus ZNF440-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF440→partner) and Y-score (partner→ZNF440) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MRPL46 →	+0.440	+3.459	<.001	.005	3	3
SKCM	MYL12A →	+0.444	+2.241	.002	.006	3	3
SKCM	UQCRC1 →	+0.517	+2.913	<.001	.001	3	3
UCEC	TIMM44 →	+0.432	+1.720	<.001	<.001	3	3
SKCM	UBE2S →	+0.612	+3.198	.002	.009	3	3
UCEC	C1QBP →	+0.539	+2.364	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,363 associations by consensus.

MRPL46 by ZNF440 expression — COAD

Explore this box plot interactively →