ZNF440

Across TCGA pan-cancer cohorts, ZNF440 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZNF440’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF440 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF440 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LIHC, and STAD are the cancer types where ZNF440 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF440 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.747	<.001	10	view →
LIHC	Female	II,III,IV	+0.739	<.001	8	view →
STAD	All	II,III,IV	+0.724	.003	6	view →
BRCA	All	II,III,IV	+0.516	<.001	6	view →
LUAD	All	III,IV	−0.567	.006	4	view →
COAD	Female	All	−0.447	.011	4	view →
CHOL	Male	All	+1.373	<.001	3	view →
HNSC	Male	All	+0.465	.020	3	view →
PAAD	All	All	+0.669	.041	2	view →
KICH	All	All	−0.483	.005	2	view →
BLCA	All	III,IV	+0.917	.038	1	view →
READ	All	II,III,IV	−0.662	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZNF440–THCA

Open the THCA breakdown →