ZNF440

Across TCGA patient cohorts, ZNF440 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF440-associated genes across cancer lineages are mTOR, PDCD4, and ATM. Each is linked with ZNF440 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF440-to-partner and partner-to-ZNF440 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by ZNF440-low versus ZNF440-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF440→partner) and Y-score (partner→ZNF440) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	-0.118	-1.289	.022	.023	3	3
UCEC	PDCD4 →	-0.416	-1.807	.005	.024	3	3
UCEC	ATM →	-0.418	-1.523	.003	.008	3	3
SKCM	TFRC →	+0.858	+3.000	.007	.036	3	3
UCEC	PCNA →	+0.189	+1.523	.006	.008	3	2
UCEC	Caspase-7-cleavedD198 →	+0.412	+1.289	.030	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

mTOR by ZNF440 expression — UCEC

Explore this box plot interactively →