ZNF440

Across TCGA cell cohorts, ZNF440 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF440-associated genes across cancer lineages are MTNR1B, WFDC8, and CCDC105. Each is linked with ZNF440 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF440-to-partner and partner-to-ZNF440 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTNR1B grouped by ZNF440-low versus ZNF440-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF440→partner) and Y-score (partner→ZNF440) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MTNR1B →	+0.053	+3.977	<.001	.005	3	1
LUNG_NSCLC_LUAD	WFDC8 →	+0.012	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	CCDC105 →	+0.003	+4.078	<.001	.009	3	1
SKIN	ALPI →	+0.010	+4.347	<.001	.001	3	1
LARGE_INTESTINE	TCF15 →	+0.345	+2.878	.008	.009	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MTNR1B by ZNF440 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →