ZNF436

Across TCGA pan-cancer cohorts, ZNF436 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF436 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ZNF436 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF436 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LSCC, LUAD, and PDAC are the cancer types where ZNF436 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	III,IV	0.537	0.877	.036	6	view →
LUAD	OS	Median	II,III,IV	0.865	0.558	.048	4	view →
PDAC	OS	Quartile	All	0.938	0.646	.012	2	view →
UCEC	DFS	Quartile	All	1.000	0.872	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF436–LSCC (OS)

Open the LSCC breakdown →